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Preimplantation Genetic Diagnosis Advantages and Disadvantages

April 25, 2012 | Comments: 0 | Views: 156

Preimplantation genetic diagnosis, or PGD for short, is a procedure that may accompany certain assisted reproductive technologies (ART) that work to create embryos through the combination of sperm and eggs. The purpose of PGD is to identify chromosome abnormalities and genetic defects in embryos to determine if the particular embryo should be transferred to the uterus. The procedure also allows for sex selection, which carries ethical questions for some. It is a procedure that should be weighed carefully and discussed with a fertility specialist when deciding if it is a service you'd like to pursue.

How do you know if you are a good candidate for preimplantation genetic diagnosis? It is often used by couples who have a history of miscarriage resulting from genetic disorders, as well as couples who have a child with a genetic disease. Therefore, they may be at a higher risk of having another child with genetic disease. Moreover, PGD may be a good option if there is a family history of X-linked disorders, as well as couples who have chromosome translocations. Translocations occur when a part of one chromosome changes places with a piece of another chromosome. If one of the partners carries an autosomal recessive disease or a autosomal dominant disease, they may be good candidates for PGD as well.

Couples should consult with a specialist to discuss prenatal diagnosis, egg donation, sperm donation, or even adoption as well. Knowing all of your options will allow you to make an informed decision, whatever that decision may be. There is a risk of misdiagnosis with PGD and other screening procedures, so couples should weigh this when making their decision. Not all genetic diseases may be identified with PGD, but the procedure is capable of identifying many of them before the embryo is ever implanted in the uterine lining. This may help to avoid a situation in which a couple may have to make a decision about terminating the pregnancy.

Embryos may have inconsistencies from one cell to the next, so the cell that is used in the biopsy may not be reflective of all other cells. This may lead to false positives and false negatives when determining test results. Additional tests may be performed early in pregnancy to confirm the results of the PGD procedure. The cost of the procedure varies from one clinic to the next, but usually adds a few thousand dollars to the cost of the assisted reproductive technology procedure.

Justin recommends to couples who are considering Preimplantation genetic diagnosis or PGD to contact Boston IVF for their higher than average IVF success rates or get more information on other pregnancy options such as surrogacy or egg donation.

Source: EzineArticles
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